Abstract: nbsp;The prescription of traditional Chinese medicine (TCM) represented by Qingfei Paidu Decoction played an important role in the prevention and treatment of COVID-19. Treatment practice of COVID-19 showed that early intervention of TCM was considerable in improving the cure rate， shortening the course， delaying disease progression， and reducing mortality rate， but the mechanisms were unclear. Based on the pathophysiological characteristics of current COVID-19 patients， we summarized the potential pathogenesis of COVID-19， which would be helpful in research of TCM against COVID-19.