| [1] |
史晓雪， 唐世琪. 阿尔茨海默病的治疗方法研究进展[J]. 职业与健康， 2018， 34(1): 134-137.
|
| [2] |
PINZ MP， DOS REIS AS， VOGT AG， et al. Current advances of pharmacological properties of 7-chloro-4-(phenylselanyl) quinoline: Prevention of cognitive deficit and anxiety in Alzheimer's disease model[J]. Biomed Pharmacother， 2018， 105: 1006-1014.
|
| [3] |
WINSLOW BT， ONYSKO MK， STOB CM， et al. Treatment of Alzheimer disease[J]. Am Fam Physician， 2011，83(12):1403-1412.
|
| [4] |
GARCIA-OSTA A， CUADRADO-TEJEDOR M， GARCIA-BARROSO C， et al. Phosphodiesterases as therapeutic targets for Alzheimer's disease[J]. ACS Chem Neurosci， 2012， 3(11): 832-844.
|
| [5] |
EFTHYMIOUA G， GOATE AM. Late onset Alzheimer's disease genetics implicates microglial pathways in disease risk[J]. Mol Neurodegeneration， 2017， 12: 43.
|
| [6] |
WU XL， PINA-CRESPO J， ZHANG YW， et al. Tau-mediated neurodegeneration and potential implications in diagnosis and treatment of Alzheimer's disease[J]. Chin Med J， 2017， 130(24): 2978-2990.
|
| [7] |
LIU Q， WANG SC， DING K. Research advances in the treatment of Alzheimer's disease with polysaccharides from traditional Chinese medicine[J]. Chin J Nat Med， 2017， 15(9): 641-652.
|
| [8] |
JESKY R， CHEN H. The neuritogenic and neuroprotective potential of senegenin against Aβ-induced neurotoxicity in PC 12 cells[J]. BMC Complement Altern Med， 2016， 16: 26.
|
| [9] |
LYU J， JIA H， JIANG Y， et al. Tenuifolin， an extract derived from tenuigenin， inhibits amyloid-β secretionin vitro[J]. Acta Physiol， 2009， 196(4): 419-425.
|
| [10] |
MAO JX， HUANG SC， LIU SF， et al. A herbal medicine for Alzheimer's disease and its active constituents promote neural progenitor proliferation[J]. Aging Cell， 2015， 14(5): 784-796.
|
| [11] |
王欣， 刘静. 孙思邈治“好忘”方特点浅析[J]. 山东中医药大学学报， 2000， 24(2): 93-94.
|
| [12] |
TRACY TE， GAN L. Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy[J]. Bioessays， 2017， 39(4)：1-9.
|
| [13] |
WU XL， PINA-CRESPO J， ZHANG YW， et al. Tau-mediated neurodegeneration and potential implications in diagnosis and treatment of Alzheimer's disease[J]. Chin Med J (Engl)， 2017， 130(24): 2978-2990.
|
| [14] |
胡慧， 王平， 孔明望， 等. 阿尔茨海默病模型大鼠Tau蛋白异常磷酸化表达及补肾化痰法的干预作用[J]. 时珍国医国药， 2010， 21(10): 2681-2683.
|
| [15] |
CUBINKOVA V， VALACHOVA B， UHRINOVA I， et al. Alternative hypotheses related to Alzheimer's disease[J].Bratislava Med J， 2018， 119(4): 210-216.
|
| [16] |
KANDEL ER. The molecular biology of memory: CAMP， PKA， CRE， CREB-1， CREB-2， and CPEB[J]. Mol Brain， 2012， 5(1): 14.
|
| [17] |
ZHANG Y， MARH， LI XC， et al. Silencing I2PP2A rescues tau pathologies and memory deficits through rescuing PP2A and inhibiting GSK-3β signaling in human tau transgenic mice[J]. Front Aging Neurosci， 2014， 6: 123.
|
| [18] |
SUZUKI A， FUKUSHIMA H， MUKAWA T， et al. Upregulation of CREB-mediated transcription enhances both short- and long-term memory[J].J Neurosci， 2011， 31(24): 8786-8802.
|
| [19] |
CHEN Y， HUANG X， ZHANG YW， et al. Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid[J]. J Neurosci， 2012， 32(33): 11390-11395.
|
| [20] |
SANDHYA VK， RAJU R， VERMA R， et al. A network map of BDNF/TRKB and BDNF/p75NTR signaling system[J]. J Cell Commun Signal， 2013， 7(4): 301-307.
|
| [21] |
VOINESKOS AN， LERCH JP， FELSKY D， et al. The brain-derived neurotrophic factor Val66Met polymorphism and prediction of neural risk for Alzheimer disease[J]. Arch Gen Psychiatry， 2011， 68(2): 198-206.
|
| [22] |
GUO HB， CHENG YF， WANG CM， et al. FFPM， a PDE4 inhibitor， reverses learning and memory deficits in APP/PS1 transgenic mice via cAMP/PKA/CREB signaling and anti-inflammatory effects[J]. Neuropharmacology， 2017， 116: 260-269.
|
| [23] |
彭英， 李萍萍， 李琳， 等. 抗阿尔茨海默病药物临床研究进展[J]. 药学学报， 2016， 51(8): 1185-1195.
|
| [24] |
汪惠琳， 徐清清， 郑国庆. 精神疾病治疗进展(四): 阿尔茨海默病[J]. 医药导报， 2017， 36(10): 1148-1152.
|
| [25] |
KLINKENBERG I， BLOKLAND A. The validity of scopolamine as a pharmacological model for cognitive impairment: A review of animal behavioral studies[J]. Neurosci Biobehav Rev， 2010， 34(8): 1307-1350.
|
| [26] |
SCHLIEBS R， ARENDT T. The cholinergic system in aging and neuronal degeneration[J].Behav Brain Res， 2011， 221(2): 555-563.
|
| [27] |
CHENG XR， ZHOU WX， ZHANG YX. The behavioral， pathological and therapeutic features of the senescence-accelerated mouse prone 8 strain as an Alzheimer's disease animal model[J]. Ageing Res Rev， 2014， 13: 13-37.
|
| [28] |
PALLAS M， CAMINS A， SMITH MA， et al. From aging to Alzheimer's disease: Unveiling “the switch” with the senescence-accelerated mouse model (SAMP8)[J]. J Alzheimer's Dis， 2008， 15(4): 615-624.
|
| [29] |
TUCKER LB， VELOSKY AG， MCCABE JT. Applications of the Morris water maze in translational traumatic brain injury research[J]. Neurosci Biobehav Rev， 2018， 88: 187-200.
|
| [30] |
PAN WS， HAN S， KANG L， et al. Effects of dihydrotestosterone on synaptic plasticity of theHippocampus in mild cognitive impairment male SAMP8 mice[J]. Exp Ther Med， 2016， 12(3): 1455-1463.
|
| [31] |
ZHANG ZX， ZHAO RP， WANG DS， et al. Fuzhisan ameliorates the memory deficits in aged SAMP8 mice via decreasing aβ production and tau hyperphosphorylation of theHippocampus[J]. Neurochem Res， 2016， 41(11): 3074-3082.
|
| [32] |
ZHANG SJ， LUO D， LI L， et al. Ethyl acetate extract components of bushen-Yizhi formula provides neuroprotection against scopolamine-induced cognitive impairment[J]. Sci Rep， 2017， 7(1): 9824.
|
| [33] |
SHI YH， HUANG WY， WANG Y， et al. Bis(9)-(-)-Meptazinol， a novel dual-binding AChE inhibitor， rescues cognitive deficits and pathological changes in APP/PS1 transgenic mice[J]. Transl Neurodegener， 2018， 7: 21.
|
| [34] |
ZHOU W， ZHONG G， FU S， et al. Microglia-based phenotypic screening identifies a novel inhibitor of neuroinflammation effective in Alzheimer's disease models[J]. ACS Chem Neurosci， 2016， 7(11): 1499-1507.
|
| [35] |
EVANS DB， RANK KB， BHATTACHARYA K， et al. Tau phosphorylation at serine 396 and serine 404 by human recombinant tau protein kinase Ⅱ inhibits tau's ability to promote microtubule assembly[J]. J Biol Chem， 2000， 275(32): 24977-24983.
|
| [36] |
IQBAL K， GRUNDKE-IQBAL I. Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease[J]. Mol Neurobiol， 1991， 5(2/3/4): 399-410.
|
| [37] |
BOLAND B， YUWH， CORTI O， et al. Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing[J]. Nat Rev Drug Discov， 2018， 17(9): 660-688.
|
| [38] |
AVILA J. Tau phosphorylation and aggregation in Alzheimer's disease pathology[J]. FEBS Lett， 2006， 580(12): 2922-2927.
|
| [39] |
BRAIDY N， ESSA MM， POLJAK A， et al. Consumption of pomegranates improves synaptic function in a transgenic mice model of Alzheimer's disease[J]. Oncotarget， 2016， 7(40): 64589-64604.
|
百度学术
下载:
