Abstract: OBJECTIVE To observe the clinical effect of Fuzheng Huowei decoction in the treatment of qi deficiency and collateral stasis type chronic atrophic gastritis (CAG). METHODS Using a random list method on SPSS， 65 patients with qi deficiency and collateral stasis type CAG were randomly divided into the treatment group with 33 cases and the control group with 32 cases. The treatment group was given Fuzheng Huowei decoction， one dose a day. The control group was given WeiFuchun Pill， three times a day， four pills each time. After three months' treatment， such indexes of the two groups were compared as traditional Chinese medicine (TCM) syndrome scores， gastroscopy， pathological effect， along with the differences of serum pepsinogen Ⅰ， Ⅱ(PGⅠ， PGⅡ)， the ratio of PGⅠ/ PGⅡ and gastrin (G-17). RESULTS After treatment， TCM syndrome scores of the two groups were lower than that before treatment (P<0.05，P<0.01) and the treatment group was better (P<0.05，P<0.01). The gastroscopy and pathological effect in the treatment group were better than that in the control group (P<0.05). The level of PGⅠ and PGR (PGⅠ/PGⅡ) in the treatment group significantly increased (P<0.05)， which was better than that in the control group (P<0.05). The total effective rate of the treatment group was 81.8%， higher than 68.8% of the control group (P<0.05). CONCLUSION Fuzheng Huowei decoction can effectively relieve the clinical symptoms of patients with CAG， improve the histopathological lesion and promote mucosal repair， of which the mechanism in treating CAG may be functioned as regulating the levels of PGⅠ， PGⅡ， PGR and G-17.