Abstract: Based on the theory of pandemic disease due to three deficiencies combined with "spectre" in the heritage chapters ofCifa Lun andBenbing Lun， inThe Yellow Emperor's Inner Classic. It is believed that the root cause of pandemic disease is due to deficiency of healthy qi and natural qi， the disharmony of human and spirit and the attack of "spectre". The theory can be beneficial to prevent pandemic disease in modern society， which helps us grasp the characteristics of the convergence of heaven qi and earth qi， personal constitution and disease condition. As for the novel epidemic diseases such as infectious diseases， it is significant to prevent and treat them under the guidance of theories in TCM， like differentiation of the convergence of heaven qi and earth qi， syndrome-differentiation of the six meridians， and the science of seasonal febrile disease and pestilential pathogen， which can also provide a vital reference in constructing the prevention and control system of the pandemic disease with TCM and reconstituting the epidemic discipline.