Abstract: The paper discussed the scientific connotation and clinical application of the compound pathogenesis of hepatocirrhosis characterized by constraint of dampness-heat and stasis-toxin. Constraint of dampness-heat and stasis-toxin was regarded as the core pathogenesis， and stasis-heat was the key link. Besides， we explored the patho-biological basis of the compound pathogenesis in modern medicine， proposed the clinical thought of clearing and removing dampness-heat and stasis-toxin， disclosed the mechanisms of regulating immune and inflammatory symptomatic response network during the progress of hepatocirrhosis with clearing and removing therapy， and provided a demonstration for the innovative research of the pathogenesis theory in traditional Chinese medicine.