Abstract: OBJECTIVE To observe the clinical efficacy of the therapeutic method of clearing heat， nourishing yin， and promoting fluid production in treating patients with exogenous high fever (severe pneumonia). METHODS 68 patients with exogenous fever (severe pneumonia) were selected and randomly divided into the experimental group and the control group. The experimental group was treated with Chinese medicinal for clearing heat， nourishing yin， and promoting fluid production plus conventional anti-infection treatment in the control group. The immediate antipyretic time， inflammation index， arterial blood gas， respiratory frequency， heart rate， imaging changes， traditional Chinese medicine (TCM) syndrome score and clinical effective rate of the two groups before and after treatment were compared to evaluate the efficacy. RESULTS The effective rate of immediate antipyretics and the lasting effect of antipyretics in the experimental group were significantly higher than those in the control group (P<0.05). As for the inflammation indicators such as white blood cells (WBC)， C-reactive protein (CRP)， procalcitonin (PCT) and imaging inflammation in terms of infiltration and absorption， the experimental group has obvious advantages (P<0.05). At the same time， it can improve the arterial blood oxygen partial pressure (PaO₂)， arterial carbon dioxide partial pressure (PaCO₂)， and average oxygenation index (PaO₂/FiO₂) more quickly (P<0.05). There was no significant difference in clinical pulmonary infection score (CPIS)， respiratory rate (RR)， and heart rate (HR) between the two groups (P>0.05). But in terms of TCM syndrome score and total effective rate， the experimental group had a significant advantage (P<0.05). CONCLUSION The method of clearing heat， nourishing yin and promoting fluid production has a notable effect in treating exogenous fever (severe pneumonia)， and it is worthy of further clinical research， promotion， and application.