Abstract: To solve water pollution and ensure water safety has become a major issue related to the long-term stability of the country. Industrial wastewater is a major source of water pollution and has become a sensitive issue related to people's well-being. It has been demonstrated that Chinese medicine pharmaceutical wastewater is one of the most difficult industrial wastewater to be treated. However， the Chinese medicine pharmaceutical industry has been in a relatively backward state in the pharmaceutical industry for a long time， with low attention and low utilization rate of new technologies. Its wastewater treatment follows the treatment methods of chemical pharmacy and microbial pharmacy. The lack of specific treatment technology for the characteristics of Chinese medicine pharmaceutical wastewater leads to the low efficiency of wastewater treatment. Whether the wastewater can be discharged as scheduled has always been a difficult problem for the development of national pharmaceutical enterprises in China. Therefore， under the background that China's economic structure has been gradually adjusted to take the green development of the industry as the main body， it is particularly important to find effective methods and paths for the effective degradation and harmless treatment of Chinese medicine pharmaceutical wastewater. In this paper， the technical problems existing in the treatment of Chinese medicine pharmaceutical wastewater were summarized， the realization path of "zero discharge" and the solution for the efficient treatment of Chinese medicine pharmaceutical wastewater were put forward， combining with the application practice in our research group. All those studies will provide a new solution strategy for the efficient treatment of Chinese medicine pharmaceutical wastewater and serve for the treatment of water pollution.