Abstract: The theory of visceral manifestation pattern differentiation proposed by professor Wu Chengyu is applied to treat triple negative breast cancer(TNBC) through combination of disease and pattern，pattern differentiation based on symptoms，identification of disease location and nature，which make complicated and intractable pattern differentiation of TNBC simpler and more precise. Liver，spleen and kidney are the main disease location and the nature of TNBC is stagnation of qi，phlegm，stasis and firetoxin. It would be more curative to treat TNBC with combination of disease and pattern from the principle of visceral manifestation pattern differentiation.