Abstract: OBJECTIVE To analyze the changes of spleen metabolic profile in mice with allergic rhinitis (AR) and the therapeutic effect and possible mechanism of Xiaofeng Xuanqiao Decoction on AR. METHEODS 60 BALB / c mice were randomly divided into control group， model group， montelukast sodium group and Xiaofeng Xuanqiao Decoction group. The AR model was established by OVA sensitization. The spleen of each group was taken out through methanol. After extraction， methoxypyridine and BSTFA were successively deuterated and derivatized. The effect of Xiaofeng Xuanqiao Decoction on the metabolic profile of AR spleen samples was analyzed by GC-MS. RESULTS The spleen metabolic profile of AR mice changed significantly. 45 kinds of metabolites were identified， mainly including pyruvic acid， lactic acid， leucine， β-alanine， benzyl alcohol， 3-hydroxybutyric acid. Xiaofeng Xuanqiao Decoction reversed 3-hydroxybutyric acid， benzoic acid， benzyl alcohol， β-alanine， ethanolamine， glycerol-1-phosphate， inosine， aspartic acid， lactic acid， phenylalanine， methanolphosphate， niacinamide， O-phosphoethanolamine， pyrophosphate， while montelukast sodium group showed no obvious return trend. CONCLUSION Xiaofeng Xuanqiao Decoction can regulate the biosynthesis of phenylalanine， tyrosine and tryptophan and β-alanine metabolism， and play a role in the treatment of AR.