Abstract: Since the outbreak of the COVID-19， TCM master Zhou Zhongying has held its pathogenesis was that the virus attacked the upper respiratory tract resulting in dampness which stagnated in the exterior and interior along with the discomfort of the lung and stomach. In addition， he proposed the commonly used syndrome differentiation proposal， including the primary stage， the intermediate stage， the severe stage and the convalescent stage. The paper analyzed the syndrome differentiation proposal from the relationship from plague and pyreticosis， pathogenesis， etiology， treatment principle， therapeutic method and treatment in stages.