Abstract: Many studies have found that in the molecular mechanism of action of traditional Chinese medicine for treating stroke， autophagy can reduce brain damage， protect nerves， protect vascular endothelial cells and promote angiogenesis. Its "two-way regulation" is consistent with the maintenance of "yin-yang balance" coordination state by Chinese medicine. Therefore， it is interesting and important to explore the correlation between the pathogenesis of traditional Chinese medicine and autophagy. Based on the theory of autophagy， autophagy responds to intracytoplasmic calcium overload， endoplasmic reticulum stress， glutamate poisoning， autophagy， and "qi deficiency" "blood stasis" and "turbidity" stroke through multiple pathways. The combination of pathogenesis and pathogenesis analyzes the similarity and correlation between the two， and proposes that the “two-way regulation” of autophagy through multiple pathways plays an important role in the occurrence， development and outcome of stroke， for further exploration. The mechanism of action in stroke is a new idea.