Abstract: Intestinal microbiome plays a messenger role in hepatocellular carcinoma， transmitting the development， progression and outcome rule of hepatocellular carcinoma，which has opened up new ways for various types of chronic liver disease and even hepatocellular carcinoma. This paper reviews the research progress of the related mechanisms of intestinal micro-intestinal microbes affecting hepatocellular carcinoma in the past decade， aiming to unearth a new way to systematically treat hepatocellular carcinoma.