Abstract: Most of the classical famous prescriptions are used in the form of decoction. In development of the granulates based on the classical famous prescriptions， how to set extracting， concentrating， drying and modeling parameters in modern manufacture to achieve an equivalent efficacy as traditional preparation， satisfy the requirements of industrial production and ensure the stable， uniform， controllable quality are key points. This review aims to explore these critical problems by combining the development of substance benchmark and standard particles in classical famous prescriptions.