Abstract: OBJECTIVE To explore the clinical effect of Acute rhinosinusitis(ARS) treated by of Biyuan Mixture and its effects on p38MAPK signaling pathway and IL-9 and IL-10 of the sinus mucosa of ARS in modeled rats. METHODS To summarize the clinical curative effects of the modeled rats，20 cases of rats in each group，which was the Chinese medicine group，western medicine group and saline group. Those rats were respectively filled the stomach with Biyuan mixture， clarithromycin dispersibl tablets and limonene and pinene enteric soft capsules， saline. Meanwhile， 5 rats were selected as the blank group. The sinus mucosa IL-9， IL-10 and p-p38 were measured before treatment， and after treatment (0， 7， 14， 21 d). And the data were recorded for statistical analysis. RESULTS According to the symptom score comparison， both Chinese medicine and western medicine have the therapeutic effects. Compared with the blank group， the levels of IL-9 and p-p38 were significantly increased. The levels of IL-9 and p-p38 in the sinus mucosa of the Chinese medicine group and the western medicine group decreased significantly with the treatment cycle (P<0.05)， and there was no significant difference between the two groups. The level of IL-10 in the sinus mucosa of the Chinese medicine group， the western medicine group and the saline group gradually increased with the treatment cycle， and there were differences between the Chinese medicine group， the western medicine group and the saline group (P<0.05)， while there was no significant difference between the Chinese medicine group and the western medicine group. CONCLUSION IL-9 and IL-10 are involved in the immune process of the onset of ARS， and there is a certain relationship with p38MAPK pathway. ARS treated by Biyuan Mixture has a definite therapeutic effect and causes changes in the level of the above substances， indicating that this prescription can promote IL-10， inhibit p-p38 activation and may block p38MAPK pathway to inhibit IL-9.