Abstract: OBJECTIVE To explore the effect of Yiqi Yangyin Tongluo formula on micro inflammatory state of patients with early diabetic nephropathy. METHODS 78 patients were randomly divided into two groups with 39 patients in each group. The control group was given conventional basic treatment， and the treatment group was treated with Yiqi Yangyin Tongluo formula on the basis of the control group. After 12 weeks， the changes of C-reactive protein (CRP)， tumor necrosis factor (TNF-α)， urinary albumin excretion rate (UAE) and clinical efficacy， TCM syndrome score， blood pressure， blood glucose， urea nitrogen (BUN)， creatinine (Scr) and other indicators in two groups were compared. RESULTS The total effective rate and TCM syndrome score improvement in the treatment group were better than those in the control group (P<0.05). Compared with pre-treatment， the levels of UAE， CRP and TNF-α in the two groups were lower (P<0.05， P<0.01)， and the improvement in the treatment group was better than that in the control group (P<0.05). No renal deterioration appeared during the observation process. CONCLUSION Yiqi Yangyin Tongluo formula can improve the symptoms of patients with early diabetic nephropathy， reduce the levels of inflammatory factors CRP， TNF-α， reduce proteinuria， and significantly interfere with the micro inflammation of early diabetic nephropathy， thus delaying the progression of diabetic nephropathy.