Abstract: OBJECTIVE To observe the clinical effect of Liuwe Buqi granule combined with Seretide on patients with chronic obstructive pulmonary disease (COPD) at stable stage (deficiency of lung and kidney qi). METHODS 60 patients with COPD at stable stage were randomly divided into control group (30 cases) and observation group (30 cases). The control group was treated with Seretide inhalation on the basis of routine western medicine treatment， and the observation group was treated with Liuwei Buqi granule on the basis of the control group for 8 weeks. The clinical efficacy and the change of acute exacerbation times， CAT score and serum amyloid A (SAA) level of the two groups were compared before and after treatment. RESULTS The total effective rates of observation group and control group were 93.33% and 70.00%( P <0.01)， respectively. After treatment， the times of acute exacerbation in observation group was significantly lower than that in control group ( P <0.01). The CAT score and the serum SAA level in the two groups were significantly decreased before and after treatment ( P <0.01). After treatment， the improvement of expectoration， fatigue and self-sweating in observation group was better than that in control group( P <0.05， P <0.01). The CAT score in observation group was significantly different from that in control group ( P <0.01). The serum SAA level in observation group was significantly lower than that in control group ( P <0.01). CONCLUSION Liuwei Buqi granules combined with Seretide can effectively improve the clinical symptoms of patients with COPD at stable stage (deficiency of lung and kidney qi)， reduce the times of acute exacerbation and reduce the level of serum SAA. The clinical curative effect is satisfactory.