Abstract: Chemotherapy induced peripheral neuropathy (CIPN) is chemotherapy drugs induced neurotoxicity occurred in anticancer treatment. Unfortunately， there is no specific clinical drug yet， only mainly symptomatic treatments with analgesics and sedative drugs are applied. CIPN can result in treatment delay，dose modification and termination of chemotherapy. Traditional Chinese medicine theory holds that CIPN is caused by arthromyodynia， previous study showed that Chinese medicine could effectively prevent the complications，but this is limited to clinical reporting， and also lacks support of sufficient evidence and system study. This Review provides a crucial update of the pathogenesis of CIPN and related signaling pathway with Chinese medicine treatment. It will provide a basic reference for the clinical treatment of CIPN.