Abstract: OBJECTIVE To observe the clinical effect of Yangyin Tianjing Huayu Mixture on cancer patients with yin deficiency and blood stasis syndrome of cancer cachexia. METHODS According to the method of single blind randomized controlled trial， 100 patients with advanced tumor were individed into two groups， the treatment group was treated with Yangyin Tianjin Huayu Mixture， the control group was treated with medroxyprogesterone acetate. Both groups were given nutritional support and symptomatic treatment. The changes of TCM syndrome score， quality of life score and laboratory indexes of two groups were observed. RESULTS The difference of TCM syndrome therapeutic effect between treatment group and control group was statistically significant (P<0.05)， and the total effective rate was 46%， superior to that of the control group(P<0.01). The difference of life quality score and the difference of TCM syndrome index score between the two groups were statistically significant. In terms of laboratory test results， the difference of hemoglobin， prealbumin and serum albumin between the treatment group and the control group was statistically significant. CONCLUSION Yangyin Tianjing Huayu Mixture can effectively improve the quality of life of the patients with yin deficiency blood stasis syndrome of cancer cachexia and significantly improve the level of hemoglobin， prealbumin and serum albumin.