宣肺法治疗感冒后咳嗽的Meta分析
Meta-Analysis on the Effect of Ventilating Lung Qi for Postinfectious Cough
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摘要: 目的 系统评价宣肺法治疗感冒后咳嗽的临床有效性及安全性。方法 通过系统检索Cochrane临床试验数据库、PubMed数据库、中国生物医学文献数据库（CBM）、中国知网CNKI、维普和万方数据库自建库到2016年9月份所有关于宣肺疗法治疗感冒后咳嗽的随机对照临床试验（RCT）文献。由两位研究者参照改良Jadad量表独立对文献进行质量评价及提取数据。对照组采用常规疗法，试验组采用宣肺疗法，或与其它疗法配合治疗。采用RevMan 5.3软件对宣肺疗法治疗感冒后咳嗽患者的咳嗽总有效率、咳嗽症状积分、咳嗽缓解时间、不良反应进行系统评价。结果 最终纳入33篇RCT文献，Meta分析结果显示，与常规治疗比较，宣肺疗法可明显提高咳嗽治疗的总有效率OR=4.10，95%CI（3.25，5.18），P<0.01，可以改善咳嗽症状积分MD=-1.93，95%CI（-2.59，-1.27），P<0.01，可以有效减少咳嗽缓解时间MD=-1.09，95%CI(-1.31，-0.87)，P<0.01，同时相对于观察组，中药组的不良反应也较低OR=0.36，95%CI(0.18，0.72)，P<0.01。结论 中医宣肺疗法治疗感冒后咳嗽具有明显优势。但由于纳入文献的质量较低，尚需要大规模、高质量的RCT提供更可靠的证据支持。Abstract: OBJECTIVE To systematically assess the efficacy and safety of Ventilating Lung Qi for the treatment of postinfectious cough. METHODS All randomized controlled trails (RCT) regarding Ventilating Lung valuation the treatment of Postinfectious cough date up to September 2016 were collected from the Cochrane library， PubMed， china biology medicine (CBM)， CNKI， VIP and Wanfang. Jadad scale was taken for quality evaluation of the included studies by two researches. The patients in the control group were given conventional treatment， the experimental group was given ventilating lung qi treatment or combined with other treatments. The total effective rate， the integral of cough symptoms， cough response time， and the adverse reactions of patients treated with Ventilating Lung Qi method were systematically evaluated by RevMan 5.3 software. RESULTS A total of 33 RCT literatures were enrolled. Meta-analysis results showed that Vantilating Lung Qi method could significantly increase the total effect rate OR=4.10，95%CI（3.25，5.18），P<0.01， in cough treatment， improve integral of cough symptom MD=-1.93，95%CI（-2.59，-1.27），P<0.01， and effectively decrease cough response time MD=-1.09，95%CI(-1.31，-0.87)，P<0.01 compared with those of the conventional treatment. And the adverse reactions in Ventilating Lung Qi group was also significantly lower OR=0.36，95%CI(0.18，0.72)，P<0.01 than that in the control group. CONCLUSION The Ventilating Lung Qi method has obvious advantages for treating postinfectious cough. But， for the low-quality of the enrolled literatures， large-scale， high-quality RC are needed to provide stronger evidence.
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