Abstract: As the core theory of TCM， viscera theory always guiding the clinical practice. This paper presented the view of heart-kidney-uterus axis， and analyzed the relationship between heart-kidney and female physiology and pathology. Female periodic rhythm was expounded from the view of heart and kidney. The movement form of heart-kidney and their alteration in female menstruation and reproductive cycle was discussed. Therefore， the clinical treatment concept of mainly regulating heart and kidney is put forward， which reveals the core of the regulation of life rhythm.