Abstract: OBJECTIVE Study the effects of Enteromorpha polysaccharides of Jiangsu province on alloxan-induced diabetic mice was studied. METHODS The diabetic mice were induced by alloxan ip， and treated with distilled water (model group)， Shenqi Jiangtang granule (500 mg/kg)， three different doses of (100， 200， and 400 mg/kg) for 28 days respectively. The changes of body weight， food and water intake were observed during administration. The content of fasting blood glucose， oral glucose tolerance， glycosylated serum albumin and serum insulin levels were measured after 28 days of treatment. The pancreatic tissues were taken for pathological observation， the islets numbers and islet area were also determined. RESULTS Medium and high dose group of can significantly reduce the fasting blood glucose level (P<0.01)， decrease the area under the curve of blood glucose (P<0.01)， increase the number of islets and islet area (P<0.01)， elevate serum insulin level (P<0.05~0.01) and high dose of can significantly reduce the content of glycosylated serum albumin (P<0.05) as compared with the diabetic model mice. CONCLUSION Within the 200~400 mg/kg dose range of can decrease blood glucose， improve glucose tolerance and relieve the pancreatic lesion levels of diabetic model mice. The results will provide a theoretical basis for the development of drugs or functional health care products of Enteromorpha polysaccharides of Jiangsu province