Abstract: OBJECTIVE To study the effect of Shenfu Qiangxin Decoction on echocardiography indexes and clinical improvement for patients with chronic heart failure with preserved ejection fraction (HFPEF) (deficiency of both yin and yang， blood stasis and water retention)， and to investigate its possible mechanism. METHODS 57 patients visited in our hospital and diagnosed as chronic HFPEF (deficiency of both yin and yang， blood stasis and water retention) from Aug. 2014 to Aug. 2015 were selected and randomly divided into the control group (28 cases) and the observation group (29 cases). The control group was given conventional therapy， and the treatment group was treated with Shenfu Qiangxin Decoction on the basis of conventional therapy， and two weeks as a course in both groups. Efficacy evaluation was performed after one course treatment. Indexes changes such as plasma brain natriuretic peptide (BNP)， 6-minute walk test (6MWT) and echocardiography in two groups were observed before and after treatment. RESULTS Plasma BNP and 6MWT in both groups improved after treatment (P<0.05~0.01)， but the observation group decreased more significantly (P<0.05). Echocardiographic indexes showed that the size of left atrial (LAD) in both groups were not significantly improved (P>0.05)， The ratio of early diastolic maximum flow velocity of mitral annulus (E peak)/early diastolic maximum velocity of tricuspid annular interventricular septum and left ventricular lateral wall tissue (Ea) and pulmonary arterial systolic pressure (PSA) of patients in two groups improved significantly(P<0.05~0.01)， change extent of the observation group was more significant compared with the control group (P<0.05). CONCLUSION Shenfu Qiangxin Decoction can effectively improve plasma BNP level， 6MWT， and echocardiography of patients with chronic HFPEF.