Abstract: OBJECTIVE To establish a method of quantitative analysis on multi-components by single marker (QAMS) to determine 5 kinds of anthraquinones in Xiaozheng capsule. METHODS Using emodin as internal referring substance，to establish the relative correction factor (f_k/s) of Aloe Emodin， rhein， chrysophanol， physcion to emodin and determine these contents. At the same time， an external standard method was established to determine the amounts of 5 kinds of anthraquinones， then compared with the QAMS method. RESULTS The two methods did not show significant difference in assay results according to the data in a certain linear range. CONCLUSION The QAMS method is feasible and credible， and can be used to determine and control the 5 kinds of anthraquinones in Xiaozheng capsule.