Abstract: OBJECTIVE To study the curative effects of Chloriti Lapis on rats with chronic obstructive pulmonary diseases(COPD). METHODS Rats models of COPD were established and were given the powder， decoction and residues of Chloriti Lapis of both high dosage and low dosage respectively based on its clinical application methods and dosage. Inflammatory factor content in rats lung tissue and blood serum was tested and relative indexes were evaluated through canonical correlation analysis， principal component analysis and multiple linear statistical models. RESULTS The high dosage group of decoction reached the best result， with the high dosage group of powder being the second and the high dosage group of residues being the third. CONCULSION Chloriti Lapis is effective in reducing inflammatory factors of both blood serum and lung tissue of rats models with COPD. The curative effect differences due to processing methods can be detected by canonical correlation analysis， principal component analysis and multiple linear statistical models.