桃红四物汤对股骨干骨折术后炎性因子和血液流变学的影响
Effects of Taohong Siwu Decoction on Inflammatory Factors and Hemorheology in Patients with Femoral Shaft Fracture After Surgery
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摘要: 目的 分析桃红四物汤对股骨干骨折术后炎性因子和血液流变学的影响。方法 以桃红四物汤治疗术后股骨干骨折67例为研究组，并以传统治疗的79例为对照组。比较2组的临床疗效、中医证候、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、肿瘤坏死因子-α (TNF-α)、全血高切黏度(η高)、全血中切黏度(η中)、全血低切黏度(η低)、血浆黏度(η浆)、红细胞比容(HCT)、白细胞计数(WBC)和血沉方程K值的变化。结果 研究组和对照组总有效率分别为97.02%和79.75% (P<0.01)；治疗后2组均能降低疼痛、肿胀、瘀斑、IL-1、IL-6、TNF-α、η高、η中、η低、η浆、HCT、WBC和血沉方程K值，与对照组比较，研究组降低更为显著(P<0.05~0.01)。结论 桃红四物汤能明显抑制股骨干骨折术后的炎症反应、改善血液流变学指标、改善临床症状。Abstract: OBJECTIVE To explore the effects of Taohong Siwu Decoction on inflammatory factors and hemorheology in patients with femoral shaft fracture after surgery. METHODS 79 patients with femoral shaft fracture after surgery in the control group were treated with conventional therapy while the equal number of patients in the study group were given Taohong Siwu Decoction. The clinical curative effect， TCM syndrome， interleukin-1(IL-1)， interleukin-6(IL-6)， tumor necrosis factor-α (TNF-α)， whole blood high shear viscosity (ηhigh)， whole blood midst shear viscosity(ηmidst)， whole blood low shear viscosity (ηlow)， plasma viscosity(ηplasm)， hematocrit value(HCT)， white blood cell(WBC) count and sedimentation equation-K value of both groups were compared. RESULTS The total curative effects of study group and control group were 97.02% and 79.75% respectively(P<0.01). Both groups experienced a decrease in pain， swelling， ecchymosis， IL1， IL6， TNFα， ηhigh， ηmidst， ηlow， ηplasm， HCT， WBC and sedimentation equation-K value and the treatment group was more superior to the control group(P<0.05~0.01). CONCULSION Taohong Siwu Decoction can significantly inhibit the inflammatory response and improve hemorheology indexes and clinical symptom for patients with femoral shaft fracture after surgery.
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