Abstract: Being a brand new medical theory and practice pattern， translational medicine represents the development tendency and inevitable requirement of modern medical science， which emphasizes the two-way rapid transformation between basic research and clinical application. Based on the relationship between traditional Chinese medicine and translational medicine， ideas and strategies for basic research of Chinese herbal compound are put forward by elaborating functions of Chinese herbal compound in translational medicine of traditional Chinese medicine and exploring its proper ways to serve clinical practice， which is not only beneficial to the innovation of traditional Chinese medicine theory and development of new clinical effective medicine， but also conductive to the discovery of new mechanisms and approaches for disease prevention and treatment as well as the illumination of principles and rules for herbal compatibility.