Abstract: OBJECTIVE To study the effects of modified Qingying Decoction on endotoxin levels of patients with cirrhosis endotoxemia due to hepatitis B. METHODS 58 patients with cirrhosis endotoxemia due to hepatitis B of toxic heat and blood stasis syndrome were randomly divided into treatment group(30 cases) and control group(28 cases). Patients in the control group were treated with hepatoprotective medication therapy， including reduced glutathione injection， Kuhuang injection and diammonium glycyrrhizinate and sodium chloride injection. Based on this， patients in the treatment group were further given Qingying Decoction. The endotoxin levels in the serum of these 58 patients were tested using the dynamic turbidity method， together with serum alanine aminotransferase(ALT)， total bilirubin(TBiL) and prothrombin time(PT). RESULTS The treatment group was superior to the control group in decreasing clinical symptom integral(P<0.01) and even more superior in reducing endotoxin levels(P<0.05). CONCULSION Qingying Decoction has a notable curative effect on cirrhosis endotoxemia due to hepatitis B.