Abstract: There have always been many controversies in chapter of jueyin diseases of Treatise on Febrile Diseases， including three aspects， namely， the doubt about main syndrome of jueyin diseases， the dispute of Wumei Pill as main prescription of jueyin diseases and the affiliation of articles on syncope， diarrhea， vomiting and hiccup. On the basis of previous studies， further investigation and discussion were made on these three issues. The pathogenesis of advance and retreat of cold-heat goes throughout the chapter of jueyin diseases， whose meaning lies in not only revealing the outcome of six-meridian diseases， but also playing a vital role in the research of various integrative cold and heat prescriptions of Zhang Zhongjing.