Abstract: OBJECTIVE To observe the effect of Sanhuang decoction in the body mass and metabolic index of patients with obesity. METHODS 64 Patients conformed to western medicine diagnosis of obesity and phlegm， dampness and heat junction were randomly divided into Sanhuang decotion group and lifestyle intervention group. After three months of treatment，comparative analysis of clinical symptoms，body mass index， waist， glucose and lipid metabolism factors and inflammatory cytokine were carried out. RESULTS Sanhuang decoction group showed better improvement in lowering body mass， waist， TG levels than the control group(P<0.05). CONCLUSION Sanhuang decoction is better in treating obesity.