Abstract: OBJECTIVE To observe the effect of Longdan Xiegan decoction in treating embolism syndrome after interventional therapy on primary hepatocellular carcinoma. METHODS Sixty patients with primary cancer after interventional therapy were randomly divided into two groups: the treatment group(30 cases) and the control group(30 cases). The control group was treated by western medicine and the treatment group， besides taking western medicine， took oral-taken Longdan Xiegan decoction as well for six weeks. RESULTS The effective rates of both groups showed no significant difference(P>0.05). After one week of treatment， the severity degree of the treatment group was much lower than that of the control group(P<0.05). After two weeks' treatment， the TCM score of the treatment group was much lower than that of the control group(P<0.05). The treatment group showed significant improvement in the TCM syndromes(P<0.05). The life quality of the treatment group was much better than that of the control group after two weeks' treatment(P<0.05). After two weeks' treatment， the treatment group showed significant decrease in the liver function(P<0.05). CONCLUSION The combination of Longdan Xiegan decoction and western medicine are more effective in treating embolism syndrome after interventional therapy on primary hepatocellular carcinoma.