Abstract: OBJECTIVE To explore the effect of Fuzheng Xiaozhi Diet (FXD) on comprehensives function of stroke patients with hemiplegia. METHODS 120 patients were randomly divided into two groups: the treatment group(60 cases) and the control group(60 cases). At the end of the study， there were 58 patients in the treatment group and 50 in the control group. Conventional treatment and care were given to both groups while Fuzheng Xiaozhi diet was added in the treatment group. Functional Comprehensive Assessment were used to assess the comprehensive function(Motor function and cognitive function) and the blood lipid level at T0， the end of three month's treatment(T1)， the end of six month's treatment(T2)， and the end of twelve month's treatment(T3). RESULTS There were significant differences in the main effects of intervention， the main effects of time on scores of motor，comprehensive functions，HDL and TC (P<0.05~0.01）， and there were significant differences in the main effects of time on scores of cognitive function and Blood lipid various indicators (P<0.05~0.01) between two groups， respectively. The scores of motor and comprehensive functions and in experiment group were higher than that in control group 3， 6 and 12 months after intervention (P<0.05~0.01). The scores of cognitive function in experiment group were higher than that in control group 6 and 12 months after intervention (P<0.05). CONCLUSION FXD can significantly improve the motor function， the cognitive function，the comprehensive functions and Lipid levels in stroke patients with hemiplegia.