Abstract: OBJECTIVE To observe the clinical efficacy of Qingdouling Mixture in treating chronic rhinitis-nasosinusitis in children. METHODS One hundred children cases with chronic rhinitis-sinusitis were randomly divided into treatment group and control group， with 50 in each. And the control group were treated with routine western treatment (antibotics for oral administration， nasal nitric oxide and mucolytics)， and control group were treated with both the above medications and Qingdouling Mixture. We made 6-month follow-ups constantly and observed clinical efficacy of 2 groups. RESULTS Compared to control group， the treatment group got more significant improvement in symptoms， body signs and state of illness. There is statistical significance between them(P<0.05). CONCLUSION Qingdouling Mixture is effective in treating chronic rhinitis-nasosinusitis in children with little recurrences and side effects.