归脾丸改善血液透析患者贫血及对炎症因子的影响
Guipi Pills in Treating Anemia of Patients Receiving Hemodialysis and the Influence on the Inflammatory Factors
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摘要: 目的 探讨归脾丸对血液透析患者贫血及炎症因子的影响。方法 60例西医诊断为慢性肾脏病（CKD）5期、CKD贫血，中医诊断为脾虚、血虚证等维持性血液透析（MHD）患者随机分成2组，每组30例。对照组采用促红细胞生成素（EPO）干预治疗，治疗组在对照组基础上加用归脾丸，共治疗60 d，2组治疗前后分别检测血红蛋白（Hb）、血清超敏C-反应蛋白（hs-CRP）、白细胞介素6（IL-6）的变化。结果 与治疗前比较，2组治疗后Hb明显升高（P<0.05~0.01），治疗组优于对照组（P<0.05）；与治疗前相比，2组患者hs-CRP、IL-6皆有明显下降（P<0.05~0.01），治疗组低于对照组（P<0.05~0.01）。结论 归脾丸具有改善血液透析患者贫血及抗炎作用。Abstract: OBJECTIVE To study on the influence of Guipi pills on anemia and the inflammatory factors of patients receiving hemodialysis. METHODS 60 patients diagnosed with CKD(stage 5)， CKD anemia and spleen deficiency and blood deficiency and have maintenance hemodialysis(MHD) were randomly divided into two groups with 30 cases in each group. The control group was treated with erythropoietin(EPO) and the treatment group， besides receiving EPO， took Guipi pills as well. The treatment lasted for 60 days. The hs-CRP， IL-6 and Hb were recorded before and after the treatment. RESULTS After the treatment， hs-CRP， IL-6 and Hb of both groups had significant decrease(P<0.05~0.01) and the treatment group was better than the control group(P<0.05~0.01). After the treatment， Hb of both groups increased(P<0.05~0.01) and still the treatment group was better than the control group(P<0.05). CONCLUSION Guipi pills are effective in treating anemia and inflammation of patients receiving hemodialysis.
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