Abstract: OBJECTIVE To explore the clinical application and features of Glycyrrhizae prescriptions with incompatible herbs by doing the survey and contrastive analysis in different third-grade class-A hospitals from the central and eastern parts of China. METHODS Clinical prescriptions containing Glycyrrhizae with incompatible herbs were collected. Association rules were utilized to analyze the compatible features of these herbs. RESULTS The drugs with the highest support in the two places are: liquorice root， seaweed， Indian bread， kelp， cassia twig， white peony root， tree peony bark， peach seed， common self-heal fruit-spike， starwort root etc. liquorice root and seaweed ranked the first in both places. The pairs of drugs highly recommended in the two places are: seaweed and liquorice root， liquorice root and Indian bread， seaweed and Indian bread， seaweed and kelp， liquorice root and kelp， liquorice root and cassia twig etc. The drug pair with the highest support in the east is liquorice root and seaweed， and then is the seaweed and kelp and liquorice root and kelp. Besides liquorice root and seaweed， the drug pair with the highest support in the middle part is liquorice root and Indian bread， and then are the Indian bread and seaweed， white peony root and liquorice root. The key pairs with high support in both places are: seaweed- liquorice root- Indian bread， seaweed-liquorice root-kelp， seaweed-liquorice root-cassia twig， liquorice root-Indian bread-cassia twig， seaweed-liquorice root- white peony root. The drug pairs with high support in the east are: liquorice root-seaweed-kelp， liquorice root-seaweed-Indian bread， liquorice root-chicken gizzard linning-seaweed， chicken gizzard linning-seaweed-Indian bread， liquorice root-chicken gizzard linning-Indian bread etc. The drug pairs with high support in the middle part are: Indian bread- liquorice root- seaweed， liquorice root- cassia twig- seaweed， white peony root- liquorice root-seaweed， Indian bread-liquorice root-cassia twig， Indian bread-tree peony bark-liquorice root etc. CONCLUSION The clinical application of Glycyrrhizae with incompatible herbs can be found， with the herbal pair of Thallus Sargassi and Glycyrrhizae being the most common one. But there exits the differences in the combined application between eastern China and central China.