Abstract: OBJECTIVE To explore the relation between hs-CRP， IL-6 in the Serum and acute cerebral hemorrhage， observe the influence of Xingnaojing Injection on hs-CRP and IL-6， expound the possible mechanism of Xingnaojing Injection for treating cerebral hemorrhage. METHODS 90 cases with acute cerebral hemorrhage were randomized into experimental group and control group. The control group were given regular treatment with ICP-lowering and styptic drugs. Experimental group were given Xingnaojing Injection on the basis of regular treatment. After 14 days' treatment， venous blood of 45 patients in experimental group and 45 patients in control group was drawn. Immunoturbidimetry was applied for detecting hs-CRP and electrochemiluminescence was applied for detecting IL-6. RESULTS The change of hs-CRP and IL-6 presented decline curve. The decline in the treatment goup is much more obvious (P<0.05~0.01). There was significant difference when the value of hs-CRP and IL-6 on the 3ir day (P<0.05). CONCLUSION Xingnaojing Injection has notable therapeutic effects on acute cerebral hemorrhage and it is probably an effective inhibitor and nervous protective agent of CRP and IL-6.