Abstract: OBJECTIVE To analyze the anti-allergy effect of Ganduqing granule and to provide experimental basis for its clinic application.METHODS The influence of Ganduqing granule on rat's skull Periost mast cells degranulation was observed and Passive skin allergy model in rats was prepared to observe the effect of Ganduqing granule on allergy.RESULTS In the rat's skull Periost mast cells degranulation rate， compared with the model group， the high-，medium-and low-dose Ganduqing granule groups were significantly decreased(P<0.05).The data of rats skin optical density in antisera injection site wew analyzed by one-way ANOVA， which showed that there was significant difference among groups in 1∶2 antisera injection site (P<0.05)， but there was no significant difference among groups in 1∶1 antisera injection site. In the PCA 1∶2 antisera injection site， compared with the model group， the optical density in the high-，medium-and low-dose Ganduqing granule groups were significantly decreased(P<0.05).CONCLUSION Ganduqing granule has a significant effect on allergy.