感毒清颗粒抗过敏作用研究

徐世军; 熊敏; 胡勇; 张荫杰; 巨少华; 代勇; 王飞; 张廷模

感毒清颗粒抗过敏作用研究

徐世军^1,2,,
熊敏^1,2,
胡勇^1,2,
张荫杰^1,2,
巨少华^1,2,
代勇³,
王飞³,
张廷模^1,2

1.
四川省中药资源系统研究与开发利用国家重点实验室培育基地，四川成都 611137
2.
成都中医药大学药学院，四川成都 611137
3.
成都中医药大学基础医学院，四川成都 611137

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出版历程
- 收稿日期: 2013-03-07
- 修回日期: 2013-04-20
- 刊出日期: 2013-05-09

Effect of Ganduqing Granule on Allergy

XUShi-Jun^1,2,,
XIONGMin^1,2,
HUYong^1,2,
ZHANGYin-Jie^1,2,
JUShao-hua^1,2,
DAIYong³,
WANGFei³,
ZHANGTing-mo^1,2

1.
Sichuan Provincial Key Laboratory, Systematic Research and Development of Chinese Medicinal Resources, Province-Ministry Co-constructed State Key Lab Incubation Base, Chengdu University of TCM, Chengdu, 611137, China
2.
School of Pharmacy, Chengdu University of TCM, Chengdu, 611137, China
3.
College of Basic Medicine, Chengdu University of TCM, Chengdu, 611137, China

摘要

摘要: 目的考察感毒清颗粒的抗过敏作用，为其临床应用提供实验依据。方法采用大鼠颅骨肥大细胞脱颗粒模型和大鼠同种被动皮肤过敏反应模型，分别观察感毒清颗粒对大鼠颅骨肥大细胞脱颗粒率和同种抗原攻击后皮肤伊文思蓝渗出抑制率的影响。结果感毒清颗粒高、中、低剂量组的大鼠颅骨肥大细胞脱颗粒率显著低于模型对照组，有显著的统计学意义（P<0.05）;大鼠背部皮下1∶1抗原血清注射点，感毒清颗粒各剂量组OD值与模型对照组无显著差异（P>0.05），但1∶2抗原血清注射点，感毒清颗粒高、中、低剂量组OD均显著低于模型对照组，有显著的统计学意义（P<0.05）。结论感毒清颗粒具有良好的抗过敏作用。
- 感毒清颗粒 /
- 抗过敏 /
- 实验研究
Abstract: OBJECTIVE To analyze the anti-allergy effect of Ganduqing granule and to provide experimental basis for its clinic application.METHODS The influence of Ganduqing granule on rat's skull Periost mast cells degranulation was observed and Passive skin allergy model in rats was prepared to observe the effect of Ganduqing granule on allergy.RESULTS In the rat's skull Periost mast cells degranulation rate， compared with the model group， the high-，medium-and low-dose Ganduqing granule groups were significantly decreased(P<0.05).The data of rats skin optical density in antisera injection site wew analyzed by one-way ANOVA， which showed that there was significant difference among groups in 1∶2 antisera injection site (P<0.05)， but there was no significant difference among groups in 1∶1 antisera injection site. In the PCA 1∶2 antisera injection site， compared with the model group， the optical density in the high-，medium-and low-dose Ganduqing granule groups were significantly decreased(P<0.05).CONCLUSION Ganduqing granule has a significant effect on allergy.
- Ganduqing granule /
- allergy /
- experiment research

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参考文献(6)

[1]	熊敏，张荫杰，徐世军，等．感毒清颗粒抗炎镇痛作用研究[J]．中药药理与临床，2012， 28（3）：89-92．
[2]	Xiong M， Zhang YJ， Xu SJ， et al.Research on Ganduqing granule anti-inflammatory and analgesia effects[J]. Pharmacol Clin Chin Mater Med， 2012， 28(3): 89-92.
[3]	Choi YH，Yan GH.Silibinin attenuates mast cell-mediated anaphylaxis-like reactions[J].Biol Pharm Bull，2009，32(5):868-875.
[4]	钟正贤，陈学芬，周桂芬，等．水半夏提取物的抗炎抗过敏作用研究[J]．中药药理与临床，2003， 19（2）：25-27．
[5]	Zhong ZX， Chen XF， Zhou GF， et al.Research on pinellia water extract anti-inflammatory and anti-allergy effects[J]. Pharmacol Clin Chin Mater Med， 2003， 19(2): 25-27.
[6]	KovarovaM， R ivera J. Amolecular understanding of mast cell activation and the promise of antiallergic the rapeutics[J]. Curr Med Chem， 2004， 11(15):2083-2091.

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感毒清颗粒抗过敏作用研究

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Effect of Ganduqing Granule on Allergy

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