Abstract: To discuss the correlation between the features of disease location and nature and the basic syndromes of the heart system by fuzzy mathematics. According to five-zang syndrome differentiation system together with "principle of proximity" in fuzzy recognition， MATLAB was used to set up the fuzzy recognition model of the basic syndrome of the heart system to test information about 1741 cases and analyze the correlation in model. The features of disease location and nature and the basic syndrome of the heart system existed fuzzy mapping relation. Most of the correlation can well reflected the features of disease location and nature of the heart system while individual correlation suggested features of mingling disease location and nature. Fuzzy mapping relation between the features of disease location and nature and the basic syndrome of the heart system is imitated effectively by fuzzy mathematics， which can be applied to five-zang syndrome differentiation system and provide a reference for the study of diseases syndrome.