Abstract: In this paper， we reviewed the relevant theories and research progress about taking Wnt/β-catenin signaling pathway as a therapeutic target for gastric cancer of TCM from both Chinese herbal monomer and compound， and put forward some problems and thoughts on the present situation of the TCM in the treatment of gastric cancer. So as to provide a certain inspiration for the scientific research of the TCM targeted intervention for the treatment of gastric cancer， and provides a reference for the application of the TCM in anti-gastric cancer.