Abstract: OBJECTIVE To observe the effect of Bushen Yiqi Huayu Jiedu Decoction on anti-hepatic fibrosis. METHODS 98 patients with hepatic fibrosis were randomly divided into two groups， 49 in each group. The control group was given Biejia Ruangan Tablet. The treatment group was given Bushen Yiqi Huayu Jiedu Decoction. After six months of treatment， the changes of clinical efficacy， TCM syndrome score， liver and kidney function， liver fibrosis index， liver and spleen B ultrasound were observed. RESULTS After treatment， the total effective rate of the treatment group was significantly higher than that of the control group (P<0.01); TCM syndrome scores in the two groups were significantly decreased (P<0.05， P<0.01)， and the treatment group was better than that of the control group (P<0.01). The contents of alanine aminotransferase (ALT)， aspartate aminotransferase (AST)， total bilirubin (TBIL)， albumin (ALB) in the treatment group decreased significantly (P<0.01)， which was more obvious than that in the control group (P<0.01). The levels of hyaluronic acid (HA)， collagen Ⅳ(Ⅳ-C)， procollagen Ⅲ(PCⅢ) in the treatment group decreased significantly (P<0.01)， which was better than that in the control group (P<0.01)， the diameters of portal vein， splenic vein and the thickness of spleen in the treatment group decreased significantly (P<0.05， P<0.01)， which was significantly better than that of the control group (P<0.01). After treatment， the B-ultrasound grade of the two groups decreased significantly (P<0.01). The liver hardness value of the treatment group was significantly lower than that of the control group(P<0.05). CONCLUSION Bushen Yiqi Huayu Jiedu Decoction shows definite anti-hepatic fibrosis effect.