Abstract: OBJECTIVE To observe the clinical effect of Toubiao Heying Jiedu recipe on patients with blood-heat psoriasis and its effect on the expression level of IL-23/Th17 axis-related cytokines in serum， so as to explore its mechanism of action. METHODS 60 patients with blood-heat psoriasis and 15 healthy controls were enrolled in the study. 30 cases in the treatment group and 30 cases in the control group were treated by oral administration of traditional Chinese medicine(TCM)， Toubiao Heying Jiedu recipe and avia A capsule respectively. The therapeutic effect was evaluated by PASI score， the level of IL-17A， IL-17F and IL-26 in serum of healthy people and psoriasis patients before and after treatment and the TCM score changes were observed. RESULTS The levels of IL-17A， IL-17F and IL-26 in serum of patients with blood-heat psoriasis were significantly higher than those of healthy people， and the difference was statistically significant(P<0.01). After treatment， the levels of IL-17A， IL-17F and IL-26 were significantly decreased (P<0.01). The treatment group was better than the control group (P<0.01). After treatment， PASI scores and TCM syndrome scores of the two groups were decreased (P<0.01). Moreover， the decrease in the treatment group was more obvious than that in the control group， and the difference was statistically significant (P<0.05， P<0.01). There was a significant difference in the incidence of adverse reactions between the two groups after treatment (P<0.01). CONCLUSION The occurrence and severity of psoriasis are related to the high expression of IL-23/Th17 axis related cytokines. Toubiao Heying Jiedu recipe have definite therapeutic effect on blood-heat psoriasis， which may play a therapeutic role by adjusting the level of IL-23/Th17 axis related factors.