左五合方对卵巢低反应者IVF/ICSI-ET助孕结局的影响
Effect of Zuowu Decoction on the Outcome of Poor Ovarian Response Patients with IVF/ICSI-ET
-
摘要: 目的 评价左五合方对卵巢低反应（POR）者体外受精/卵胞质内单精子注射-胚胎移植(IVF/ICSI-ET)卵巢反应性、妊娠相关指标的影响。方法 将100例肾精不足合脾气虚型POR患者随机分为治疗组和对照组各50例，2组均常规行IVF/ICSI-ET，其中治疗组以左五合方治疗3月再行IVF/ICSI-ET。比较2组患者促性腺激素（Gn）用量及用药天数、人绒毛膜促性腺激素（HCG）注射日雌二醇（E2）及孕酮（P）水平、获卵数、优胚率、生化妊娠率、临床妊娠率、持续妊娠率。结果 2组Gn用量及用药天数、HCG日E2和P水平、优胚率、生化妊娠率差异均无统计学意义（P>0.05）；治疗组获卵数、临床妊娠率、持续妊娠率均高于对照组（P<0.05）。结论 左五合方能提高POR者IVF/ICSI-ET的获卵数、临床妊娠率和持续妊娠率。
-
关键词:
- 左五合方 /
- 卵巢低反应 /
- 体外受精/卵胞质内单精子注射-胚胎移植
Abstract: OBJECTIVE To evaluate the impact of Zuowu decoction on ovarian response and pregnancy related indicators of poor ovarian response (POR) patients with in vitro fertilization/ intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET). METHODS 100 patients with POR due to deficiency of kidney-essence and spleen-qi were randomly divided into the treatment group and the control group with 50 cases in each. Both groups received routine IVF/ICSI-ET while the treatment group was pre-administrated with Zuowu Decoction for 3 months， and then given IVF/ICSI-ET. The dosage and administration duration of gonadotropin (Gn)， the levels of estradiol (E2) and progesterone (P) on human chorionic gonadotropin(HCG) trigger day， number of retrieved oocytes， high-quality embryo rates， biochemical pregnancy rate， clinical pregnancy rate and ongoing pregnancy rate were compared between the two groups. RESULTS The differences of the following indicators were no statistically significant: the dosage and administration duration of Gn， the level of E2 and P on HCG trigger day， high-quality embryo rates and biochemical pregnancy rate (P>0.05). The number of retrieved oocytes， clinical pregnancy rate and ongoing pregnancy rate in the treatment group were all higher than those in the control group (P<0.05). CONCLUSION Zuowu Decoction can increase the number of retrieved oocytes， clinical pregnancy rate and ongoing pregnancy rate in POR patients with IVF/ICSI-ET treatment.-
Keywords:
- Zuowu Decoction /
- poor ovarian response /
- IVF/ICSI-ET
-
-
[1] 武学清，孔蕊，田莉，等.卵巢低反应专家共识[J].生殖与避孕，2015，35(2):71-79. [2] EBRAHIMI M， AKBARIASBAGH F， GHALANDARATTAR M. Letrozole+ GnRH antagonist stimulation protocol in poor ovarian responders undergoing intracytoplasmic sperm injection cycles: An RCT[J]. Int J Reprod Biomed， 2017， 15(2):101-108. [3] DUPORT PM， ANAHORY T， RANISAVLJEVIC N， et al. Poor responders: How could we improve our results?[J].Gynecol Obstetriq Fertil Senol，2017， 45(2):95-103. [4] TARLATZIS BC， ZEPIRIDIS L， GRIMBIZIS G， et al. Clinical management of low ovarian response to stimulation for IVF: a systematic review[J]. Hum Reprod Upd， 2003， 9(1):61-76. [5] FERRARETTI AP， LA MARCA A， FAUSER BC，et al. ESHRE consensus on the definition of poor response to ovarian stimulation for in vitro<\i> fertilization:the Bologna criteria[J].Hum Reprod，2011，26(7):1616-1624. [6] 成都中医药大学.中医诊断学[M].成都：四川科学技术出版社，2007:313-314. [7] 中药新药临床研究指导原则[S].北京：中国医药科技出版社，2002:388-389. [8] STEER CV， MILLS CL， TAN SL， et al. The cumulative embryo score: A predictive embryo scoring technique to select the optimal number of embryos， to transfer in an in-vitro fertilization and embryo transfer programme[J]. Hum Reprod， 1992， 7(1):117-119. [9] MUSTAFA KB， KEANE KN， WALZ NL， et al. Live birth rates are satisfactory following multiple IVF treatment cycles in poor prognosis patients[J]. Reprod Biol， 2016， 17(1):34-41. [10] 黄帝内经素问[M].北京:人民卫生出版社，1963:4-5. [11] 张介宾.景岳全书[M].北京:中国中医药出版社，1996:1091. -
期刊类型引用(3)
1. 孟俊玲，汤莉. 桃红四物汤加减联合助卵泡汤分阶段口服对IVF-ET中卵巢低反应患者卵巢反应性及卵子质量的影响. 陕西中医. 2023(09): 1205-1207 . 
百度学术
2. 姚俐，黄倩文，黄莉，孙小丽，张曦倩. 滋肾调冲法和生长激素对不同年龄卵巢储备功能减退患者体外受精胚胎移植结局的影响. 中国医院用药评价与分析. 2021(05): 530-533+538 . 百度学术
3. 顿巨燕，田丽颖，王芬，柯琴. 固肾安胎方联合黄体酮注射液治疗对早期先兆流产患者临床效果、症状体征及激素水平的影响. 解放军医药杂志. 2021(07): 110-113 . 百度学术
其他类型引用(1)
计量
- 文章访问数: 717
- HTML全文浏览量: 5
- PDF下载量: 490
- 被引次数: 4
下载:
