Abstract: OBJECTIVE To observe the clinical effect of Shexiang Baoxin pill combined with thermal moxibustion treating coronary heart disease angina pectoris.METHODS 124 inpatients with coronary heart disease angina pectoris in our hospital were randomly divided into two groups， 62 each. Besides positive control of blood pressure and blood glucose， the control group was given standard western medicine treatment: oral antiplatelet drugs， nitrates， β-blockers and statins. The treatment group was treated with Shexiang Baoxin pill combined with thermal moxibustion on the basis of the control group. The clinical efficacy， the changes of serum levels of inflammatory factors， the changes of blood lipid levels， QT interval dispersion (QTd)， cardiac ischemia-related events and other factors in the two groups before and after the treatment were compared. As for the changes of serum levels of inflammatory factors， C-reactive protein (CRP)， interleukin-6 (IL-6)， tumor necrosis factor-α (TNF-α) were assessed while for the changes of blood lipid levels， triglyceride (TG)， cholesterol (TC)， low density lipoprotein (LDL-C) were observed. RESULTS After treatment， the levels of serum inflammatory factors (CRP， IL6， TNF-α)， blood lipid levels (TG， TC， LDL-C) and QT dispersion were improved in both groups (P<0.05，P<0.01). The improvement of the treatment group was significantly better than that of the control group (P<0.05，P<0.01). The occurrence of ischemia-related events in the treatment group was significantly reduced compared with that in the control group (P<0.01). CONCLUSION Shexiang Baoxin pill combined with thermal moxibustion can effectively improve the clinical symptoms and life quality of patients with coronary heart disease angina pectoris， and significantly reduce the occurrence of ischemia-related events.