Abstract: Patients with breast cancer given drug ovarian castration and chemeotherapy suffer from ovarian suppression symptoms， similar to symptoms due to menopausal syndrome， such as excessive heart and liver fire and deficient kidney yin. National Medical Master Professor Xia Gui-cheng put forward the "heart-kidney-uterine axis" regulation theory， emphasizing heart-kidney interaction and water and fire counteraction， as well as created Qingxin Zishen Decoction to treat climacteric diseases. Because of the similarity between the two， Qingxin Zishen Decoction can also be used to improve ovarian suppression in young patients with breast cancer， and the clinical effect is significant， which is worthy of further observation and application.