Abstract: One of the major risk factors for cardiovascular disease is arterial stiffness. There are several mechanisms associated with the development of arterial stiffness, including the involvement of advanced glycation end products. Arterial stiffness results from altered distensibility of arterial walls and is associated with advanced glycation end productrelated crosslinking of collagen in the artery matrix. Oxidative stress is associated with advanced glycation end products formation and triggered by moodiness, feeding mode, and lifestyle. In TCM and care, the major treatment for arterial stiffness includes activating blood, resolving stasis, softening hardness, and dissipating binds. Depending on the particular syndrome, variations on these major approaches to TCM therapy and related auxiliary nursing care are applied.