Abstract: This paper analyzes the theories of ancient physicians on ministerial fire diseases， and summarizes the meanings， physiological functions， pathological features， syndromes and prescriptions of ministerial fire diseases. It is believed that there is ministerial fire in the life gate， liver， gallbladder and triple energizer. And the root of ministerial fire is life gate， which dominates the heart in the upper part， while ministerial fire is static and hidden， and the intrinsic life is kept in the life gate (right kidney)， while movement are sent to the viscera such as liver， gallbladder and triple energizer. The ministerial fire is dominate sex and reproduction， which can promote spiritual exchange. Clinical treatment should be based on syndrome differentiation of deficiency and excess.