Abstract: This article summarized Professor XU Zhiyin's clinical experience in the treatment of nodular goiter. Professor XU believes that the basic pathogenesis of nodular goiter is the qi stagnation， and intercross of phlegm and blood stasis. Clinically， the treatment should be comprehensively performed form promoting qi circulation， removing phlegm， eliminating blood stasis， combined with warming yang， dissipating tubercles， soothing the liver and regulating qi.