Abstract: Renal fibrosis is the pathological basis of the progression of various chronic renal diseases to end-stage renal disease， which is life-threatening. Its pathogenesis is complex and is involved in a variety of cytokines and signaling pathways， and there is no effective therapeutic drug until now. In recent years， on the basis of TCM theory of renal fibrosis and its molecular mechanism， through randomized multicenter clinical study and basic research in vitro and in vivo， our hospital confirmed that a variety of Chinese herbs and their effective components have the effect of delaying renal fibrosis， and we have identified their action target. In a word， we should continue to find effective Chinese medicine that can postpone renal fibrosis， to confirm their curative effect， especially to clear their action mechanism.