Abstract: This paper introduces professor ZHOU Zhongying's experience for differentiating and treating colon cancer， which includes spleen deficiency and stomach weakness， damp heat accumulation and turbid stagnation. During the clinical syndrome differentiation， professor ZHOU Zhongying combines with other compliant syndromes such as qi stagnation， blood stasis， phlegm retention， collaterals disorders due to the long-term illness， and usually takes strengthening spleen resolving phlegm as the main treating methods. He also takes fighting against cancer and purifying toxin as the method of differentiating disease， and takes regulating the flow of qi and smoothing stagnation， removing phlegm and resolving hard masses， promoting blood circulation to remove blood stasis， seeking and activating collaterals as the referential principles. He especially stresses on the principle of clearing away heat and removing turbidity.