Abstract:  The processing theory of seed drugs be stir-heated before using for the seed medicine has a rich scientific connotation. However， the internal chemical changes and changing laws are not clear， the effective substances are not definite， and characteristic quality standards are in need， so it is difficult to control the quality of the seed drugs effectively. When processing the Chinese herbal medicines， the same technical methods may cause some common reactions frequently. Revealing the common mechanism of seed drugs be stir-heated before using in this further study has guiding meaning to establish characteristic quality standards. On the basic of the theory of seed drugs be stir-heated， this study will use the spectrum-activity relationship method to study the changes of the chemical composition and pharmacological effect， clarify the effective basis， and reveal common mechanism during the stir-frying process. Meanwhile， this paper will use pharmacokinetics method to clarify the effective substances in vivo of Chinese medicine. On this basis， multi-components by one marker， LC-MS and other methods will be employed to establish characteristic standards for these seed drugs， and then to guide the standardized production and clinical use of seed drugs.