Abstract: OBJECTIVE To observe the clinical effects of Futong Xiere Formula from professor Huang Bao-zhong， a distinguished veteran doctors of TCM， in treating hepatic coma due to cirrhosis of liver and upper gastrointestinal bleeding through nasal feeding. METHODS 40 cases diagnosed with decompensated liver cirrhosis combined with upper gastrointestinal bleeding and hepatic coma in our hospital were collected from August， 2007 to December， 2012 and divided into observation group and treatment group， with 20 cases in each group. Patients in the control group were given conventional treatment including stopping bleeding， resisting hepatic coma， protecting liver and supporting therapy. Based on this， patients in the observation group were further given Futong Xiere Formula through nasal feeding. Then the clinical effects were analyzed between the two groups， together with hospitalization time and costs. RESULTS The total curative rate was 90% in the observation group and 60% in the control group. The observation group was superior to the control group in reducing total bilirubin and blood ammonia level(P<0.05). CONCLUSION Conventional treatment combined with herbal therapy through nasal feeding based on syndrome differentiation can efficiently stop bleeding， improve coma condition and enhance the results.